Understanding the Synthetic Compound, SAMe

SAMe, also known as SAM-e and S-adenosylmethione, is a synthetic form of a naturally occurring compound found in the body. This compound is made from the methionine and adenosine triphosphate. This compound is essential for producing energy in the cells.

Why Use SAMe Supplements

SAMe supplements are beneficial for a variety of health conditions. SAMe supplements have been studied for their use with people who have osteoarthritis. The results have been positive, showing that the supplement is useful in treating the pain associated with osteoarthritis. Pain treatment was as effective as using typical non-steroidal anti-inflammatory prescriptions for pain and it did not have side effects.

Liver Disease is another are that SAMe supplements are showing promise in helping. Early stages of research suggest that the SAMe supplement may be able to help the liver enzyme levels return to normal.

SAMe may also be helpful in the treatment of cholestasis a disease of the liver in which the flow of bile to the duodenum is stopped or slowed. This condition results in damage to the liver and the ensuing health conditions related to liver disease.

SAMe has been studied by a number of researchers to determine what effect it has on depression. Some results point to the increase of serotonin and dopamine production, two neurotransmitters in the brain.

Using SAMe supplements can have side effects and long term effects are not completely known at this time as tests are still underway to determine what if any those might be.

Currently, the safety of SAMe’s use during pregnancy or breastfeeding is not known. It is safe to say that no supplement should be used while pregnant or breastfeeding without consent from the doctor.

Individuals with bipolar disorder, anxiety disorder or other emotional or psychiatric disorders should not use SAMe supplements unless advised to do so by their doctors. This supplement has been linked to manic and hypomanic episodes. This could be due to its relationship to the production of serotonin and dopamine.

Side Effects

As with any medications or supplements, individuals need to be aware of any possible side effects. The most common ones seen with SAMe supplements are gastro related, particularly queasiness and nausea. Other reported side effects include lowered blood sugar levels, skin rash, dry mouth, increased urinary activity, headache and insomnia.

SAMe supplements should be taken on an empty stomach and with plenty of water. They should be taken early in the day due to the propensity to cause insomnia.
SAMe supplements are available on the Internet at Nature Made’s website. Here, consumers can find answers to many of their questions and even a contact form if more information is desired. Nature Made has also set up a sub website specifically for educating the public on SAMe supplements.

Consumers should read this information, educate themselves on the supplement and talk to their doctor before beginning a program using SAMe supplements.